Treatment of OP poisoning consists of intravenous atropine and oximes. Early diagnosis and appropriate treatment is often life saving. The mortality rate of OP poisoning is high. The inhibition of acetylcholinesterase causes accumulation of acetylcholine at synapses, and overstimulation of neurotransmission occurs as a result of this accumulation. Emergency Medicine News.Organophosphate (OP) insecticides inhibit both cholinesterase and pseudo-cholinesterase activities. Toxicology Rounds: Atropine Dosing Regimen Suboptimal for Organophosphate Poisoning. Management of acute organophosphorus pesticide poisoning. Eddleston M, Buckley NA, Eyer P, Dawson AH.Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors. Eddleston M, Dawson A, Karalliedde L, Dissanayake W, Hittarage A, Azher S, Buckley NA.Oximes for acute organophosphate pesticide poisoning. Buckley NA, Eddleston M, Li Y, Bevan M, Robertson J.Open-label randomized clinical trial of atropine bolus injection versus incremental boluses plus infusion for organophosphate poisoning in Bangladesh. Abedin MJ, Sayeed AA, Basher A, Maude RJ, Hoque G, Faiz MA.activated charcoal if presents with 1-2 hours.benzodiazepines: midazolam 0.2mg/kg, seizures or agitation.

pralidoxime chloride 30mg/kg IV -> 8mg/kg/hr: muscle weakness.atropine: 0.02mg/kg boluses -> recurrent boluses q5min doubling the dose each time, treats bradycardia, hypotension and excess secretion production.haemodynamic monitoring and management with the below agents.aspiration/bronchospasm/seizures may necessitate airway protection and mechanical ventilation.butyrylcholinesterase or acetylcholinesterase activity.SLUDGE: salivation, lacrimation, urination, defaecation, emesis.DUMBBELS: diarrhoea, urination, miosis, bronchorhea, bradycardia, emesis, lacrimation, salivation.covalent bonding with inactivation of acetylcholinesterase.common cause of poisoning in the developing world.

Antidote for organophosphate poisoning